Integrin beta 4 anticorps (pTyr1510)

N° du produit ABIN7221910

Cet anticorps Lapin Polyclonal détecte spécifiquement Integrin beta 4 dans WB, IHC, ELISA et IF. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Integrin beta 4 anticorps (pTyr1510) (ABIN7221910)

Antigène: Integrin beta 4 (ITGB4)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Integrin beta 4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-Integrin beta 4 anticorps

Épitope: pTyr1510

Fonction: Rabbit Anti-Integrin β4 (phospho Tyr1510) Polyclonal Antibody

Specificité: Phospho-Integrin β4 (Y1510) Polyclonal Antibody detects endogenous levels of Integrin β4 protein only when phosphorylated at Y1510.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human Integrin beta4 Phospho-Tyr1510

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:10000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Integrin beta 4

Antigène: Integrin beta 4 (ITGB4)

Autre désignation: Integrin beta4

Sujet: ITGB4, Integrin beta-4, GP150, CD antigen CD104Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. ITGB4 encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Poids moléculaire: 202kD

ID gène: 3691

UniProt: P16144

Pathways: Integrin Complex