Macrophage Scavenger Receptor 1 anticorps (AA 241-290)

N° du produit ABIN7227706

L’anticorps anti-Macrophage Scavenger Receptor 1 Polyclonal Lapin est utilisé pour la détection de Macrophage Scavenger Receptor 1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA, IHC et IF.

Aperçu rapide pour Macrophage Scavenger Receptor 1 anticorps (AA 241-290) (ABIN7227706)

Antigène: Macrophage Scavenger Receptor 1 (MSR1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Macrophage Scavenger Receptor 1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Macrophage Scavenger Receptor 1 anticorps

Épitope: AA 241-290

Fonction: Rabbit Anti-CD204 Polyclonal Antibody

Specificité: The antibody detects endogenous levels of CD204

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human CD204 protein at AA range: 241-290

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200,ELISA 1:10000-20000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Macrophage Scavenger Receptor 1

Antigène: Macrophage Scavenger Receptor 1 (MSR1)

Autre désignation: CD204

Sujet: Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD antigen CD204MSR1 encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of MSR1. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

ID gène: 4481

UniProt: P21757