MMP2 anticorps

N° du produit ABIN7212276

Cet anticorps anti-MMP2 Monoclonal Souris (Clone 1H1) (ABIN7212276) détecte spécifiquement MMP2 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour MMP2 anticorps (ABIN7212276)

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivité: Humain, Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MMP2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1H1

Détail du produit anti-MMP2 anticorps

Fonction: MMP2 Mouse Monoclonal Antibody (1H1)

Specificité: MMP2 protein detects endogenous levels of MMP2.

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen

Immunogène: Synthetic Peptide of MMP2 at AA range of INTERNAL

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:200).

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur MMP2

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Autre désignation: MMP2

Sujet: Mouse Anti-MMP2 Mouse Monoclonal Antibody (1H1),MMP2,MMP2 (matrix metallopeptidase 2) is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in MMP2 have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.,MMP2

Poids moléculaire: observerd band 64,72kDa

ID gène: 4313

UniProt: P08253

Pathways: Activation of Innate immune Response