MED23 anticorps (AA 10-90)

N° du produit ABIN7214346

L’anticorps anti-MED23 Polyclonal Lapin est utilisé pour la détection de MED23 dans des échantillons de Humain, Rat et Souris. Il a été validé pour ELISA, WB, IHC et IF.

Aperçu rapide pour MED23 anticorps (AA 10-90) (ABIN7214346)

Antigène: MED23 (Mediator Complex Subunit 23 (MED23))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MED23 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-MED23 anticorps

Épitope: AA 10-90

Fonction: Rabbit Anti-CRSP130 Polyclonal Antibody

Specificité: CRSP130 Polyclonal Antibody detects endogenous levels of CRSP130 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the N-terminal region of human CRSP130 at AA range: 10-90

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur MED23

Antigène: MED23 (Mediator Complex Subunit 23 (MED23))

Autre désignation: CRSP130

Sujet: MED23, ARC130, CRSP3, DRIP130, KIAA1216, SUR2, Mediator of RNA polymerase II transcription subunit 23, Activator-recruited cofactor 130 kDa component, ARC130, Cofactor required for Sp1 transcriptional activation subunit 3, CRSP complex subuThe activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. Mediator complex subunit 23 encoded by MED23 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor- (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for MED23.

Poids moléculaire: 150kD

ID gène: 9439

UniProt: Q9ULK4

Pathways: Regulation of Lipid Metabolism by PPARalpha