MAP4K2 anticorps (AA 400-480)

N° du produit ABIN7229498

L’anticorps anti-MAP4K2 Polyclonal Lapin est utilisé pour la détection de MAP4K2 dans des échantillons de Humain et Souris. Il a été validé pour WB et ELISA.

Aperçu rapide pour MAP4K2 anticorps (AA 400-480) (ABIN7229498)

Antigène: MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP4K2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MAP4K2 anticorps

Épitope: AA 400-480

Fonction: Rabbit Anti-M4K2 Polyclonal Antibody

Specificité: The antibody detects endogenous levels of M4K2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human M4K2 protein at AA range: 400-480

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur MAP4K2

Antigène: MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))

Autre désignation: M4K2

Sujet: Mitogen-activated protein kinase kinase kinase kinase 2, B lymphocyte serine/threonine-protein kinase, Germinal center kinase, GC kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, MEKKK 2, Rab8-interacting proteinThe protein encoded by MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2) is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. MAP4K2 is a Protein Coding gene. Diseases associated with MAP4K2 include Cerebral Cavernous Malformations-2. Among its related pathways are TGF-Beta Pathway and MAPK signaling pathway.

Poids moléculaire: 90kD

ID gène: 5871

UniProt: Q12851