NDFIP2 anticorps

N° du produit ABIN7229980

Cet anticorps Lapin Polyclonal détecte spécifiquement NDFIP2 dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour NDFIP2 anticorps (ABIN7229980)

Antigène: NDFIP2 (Nedd4 Family Interacting Protein 2 (NDFIP2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NDFIP2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-NDFIP2 anticorps

Fonction: Rabbit Anti-NFIP2 Polyclonal Antibody

Specificité: The antibody detects endogenous levels of NFIP2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human NFIP2 protein

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur NDFIP2

Antigène: NDFIP2 (Nedd4 Family Interacting Protein 2 (NDFIP2))

Autre désignation: NFIP2

Sujet: NEDD4 family-interacting protein 2, NEDD4 WW domain-binding protein 5A, Putative MAPK-activating protein PM04/PM05/PM06/PM07, Putative NF-kappa-B-activating protein 413NDFIP2 (Nedd4 Family Interacting Protein 2) is a Protein Coding gene. Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation. May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination.

Poids moléculaire: 36kD

ID gène: 54602

UniProt: Q9NV92

Pathways: Negative Regulation of Transporter Activity, SARS-CoV-2 Protein Interactome