Nodal anticorps (C-Term)

N° du produit ABIN7226708

Cet anticorps Lapin Polyclonal détecte spécifiquement Nodal dans WB, ELISA, IHC et IF. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Nodal anticorps (C-Term) (ABIN7226708)

Antigène: Nodal (NODAL) (Nodal Homolog (NODAL))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nodal est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Nodal anticorps

Épitope: C-Term

Fonction: Rabbit Anti-Nodal Polyclonal Antibody

Specificité: Nodal Polyclonal Antibody detects endogenous levels of Nodal protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the C-terminal region of human Nodal

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC: 1:100-1:300,ELISA 1:10000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Nodal

Antigène: Nodal (NODAL) (Nodal Homolog (NODAL))

Autre désignation: Nodal

Sujet: NODAL, Nodal homologNODAL (nodal growth differentiation factor) encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in NODAL are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis.

Poids moléculaire: 40kD

ID gène: 4838

UniProt: Q96S42

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance, Tube Formation, Positive Regulation of Endopeptidase Activity