NOTCH4 anticorps (Cleaved-Val1432)

N° du produit ABIN7222800

Cet anticorps Lapin Polyclonal détecte spécifiquement NOTCH4 dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain, Souris et Singe.

Aperçu rapide pour NOTCH4 anticorps (Cleaved-Val1432) (ABIN7222800)

Antigène: NOTCH4 (Notch 4 (NOTCH4))

Reactivité: Humain, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOTCH4 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-NOTCH4 anticorps

Épitope: AA 1370-1450, Cleaved-Val1432

Fonction: Rabbit Anti-Cleaved-Notch 4 (V1432) Polyclonal Antibody

Specificité: Cleaved-Notch 4 (V1432) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 4 protein resulting from cleavage adjacent to V1432.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the C-terminal region of human Notch 4 at AA range: 1370-1450

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur NOTCH4

Antigène: NOTCH4 (Notch 4 (NOTCH4))

Autre désignation: Notch 4

Sujet: NOTCH4, INT3, Neurogenic locus notch homolog protein 4, Notch 4, hNotch4NOTCH4 encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in NOTCH4 may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Poids moléculaire: 59kD

ID gène: 4855

UniProt: Q99466

Pathways: Signalisation Notch