PKA anticorps (AA 1-80)

N° du produit ABIN7216582

L’anticorps Lapin Polyclonal anti-PKA a été validé pour WB, ELISA, IHC (p) et IF. Il convient pour détecter PKA dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PKA anticorps (AA 1-80) (ABIN7216582)

Antigène: PKA (Protein Kinase A (PKA))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKA est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-PKA anticorps

Épitope: AA 1-80

Fonction: PKAα/β cat Polyclonal Antibody

Specificité: PKAα/β cat Polyclonal Antibody detects endogenous levels of PKAα/β cat protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from the N-terminal region of human PKAalpha/beta cat at AA range: 1-80

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:20000). Not yet tested in other applications.

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur PKA

Antigène: PKA (Protein Kinase A (PKA))

Autre désignation: PKAalpha/beta

Sujet: Rabbit Anti-PKAα/β cat Polyclonal Antibody,PRKACA, PKACA, cAMP-dependent protein kinase catalytic subunit alpha, PKA C-alpha, PRKACB, cAMP-dependent protein kinase catalytic subunit beta, PKA C-beta,PRKACA encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of PRKACA caused either by somatic mutations, or genomic duplications of regions that include PRKACA, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.,cAMP-dependent protein kinase catalytic subunit alpha

Poids moléculaire: observerd band 38kDa

ID gène: 5566, 5567

Pathways: SARS-CoV-2 Protein Interactome