RCC1 anticorps (AA 301-350)

N° du produit ABIN7226940

Cet anticorps Lapin Polyclonal détecte spécifiquement RCC1 dans WB et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour RCC1 anticorps (AA 301-350) (ABIN7226940)

Antigène: RCC1 (Regulator of Chromosome Condensation 1 (RCC1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RCC1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-RCC1 anticorps

Épitope: AA 301-350

Fonction: RCC1 Polyclonal Antibody

Specificité: The antibody detects endogenous RCC1 protein.

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogène: Synthetic peptide from human protein at AA range: 301-350

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:10000), ELISA (1:10000).

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur RCC1

Antigène: RCC1 (Regulator of Chromosome Condensation 1 (RCC1))

Autre désignation: RCC1

Sujet: Rabbit Anti-RCC1 Polyclonal Antibody,RCC1, CHC1,The Ras family small GTPase Ran is involved in nuclear envelope formation, assembly of the mitotic spindle and nuclear transport. Like other small GTPases, Ran is active in its GTP-bound form and inactive in its GDP-bound form. Nuclear RanGTP concentration is maintained through nuclear localization of guanine nucleotide exchange factor (GEF) activity, which catalyzes the exchange of bound GDP for GTP. RCC1 (regulator of chromatin condensation 1) is the only known RanGEF. RCC1 is dynamically chromatin-bound throughout the cell cycle, and this localization is required for mitosis to proceed normally. Appropriate association of RCC1 with chromatin is regulated through amino-terminal phosphorylation and methylation. RCC1 regulation of RanGTP levels in response to histone modifications regulates nuclear import during apoptosis. In mitosis RCC1 is phosphorylated at Ser11, possibly by cyclinB/cdc2. This phosphorylation may play a role in RCC1 interaction with chromatin and its RanGEF activity.,regulator of chromosome condensation 1, SNHG3-RCC1 readthrough transcript

Poids moléculaire: observerd band 45kDa

ID gène: 1104

UniProt: P18754

Pathways: Chromatin Binding, Protein targeting to Nucleus