DDR1 anticorps (pTyr513) (Cy5)

N° du produit ABIN716640

Cet anticorps anti-DDR1 est un anticorps Lapin Polyclonal détectant DDR1 dans WB, IF (p) et IF (cc). Adapté pour Humain.

Aperçu rapide pour DDR1 anticorps (pTyr513) (Cy5) (ABIN716640)

Antigène: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDR1 est conjugé à/à la Cy5

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Détail du produit anti-DDR1 anticorps (Cy5)

Épitope: pTyr513

Réactivité croisée: Humain

Homologie: Mouse,Rat,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human MCK10 around the phosphorylation site of Tyr513

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur DDR1

Antigène: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Autre désignation: MCK10

Sujet:

Synonyms: MCK10 phospho Y513, p-MCK10 phospho Y513, CAK, CD167a, DDR1CD 167, CD167, Cell adhesion kinase, DDR 1, DDR, DDR1, Discoidin domain receptor, Discoidin receptor tyrosine kinase isoform a, EDDR 1, Epithelial discoidin domain receptor 1, Epithelial specic receptor kinase, Mammarian carcinoma kinase 10, Neuroepithelial tyrosine kinase, Neurotrophic tyrosine kinase receptor type 4, NTRK 4, PTK 3, PTK 3A protein tyrosine kinase 3A, Receptor tyrosine kinase NEP, RTK 6, TRK E, Tyrosine kinase receptor E, DDR1_HUMAN.

Background: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

ID gène: 780

UniProt: Q08345

Pathways: Signalisation RTK, Smooth Muscle Cell Migration