SPAG8 anticorps

N° du produit ABIN7231482

L’anticorps anti-SPAG8 Polyclonal Lapin est utilisé pour la détection de SPAG8 dans des échantillons de Humain et Souris. Il a été validé pour ELISA et WB.

Aperçu rapide pour SPAG8 anticorps (ABIN7231482)

Antigène: SPAG8 (Sperm Associated Antigen 8 (SPAG8))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPAG8 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-SPAG8 anticorps

Fonction: Rabbit Anti-SPAG8 Polyclonal Antibody

Specificité: The antibody detects endogenous levels of SPAG8 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human SPAG8 protein

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur SPAG8

Antigène: SPAG8 (Sperm Associated Antigen 8 (SPAG8))

Autre désignation: SPAG8

Sujet: Sperm-associated antigen 8, HSD-1, Sperm membrane protein 1, SMP-1, Sperm membrane protein BS-84The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. Sperm Associated Antigen 8 encoded by SPAG8 is recognized by sperm agglutinating antibodies from an infertile woman. Sperm Associated Antigen 8 is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Sperm Associated Antigen 8 interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator) -ACT-mediated gene transcription during spermatogenesis. Sperm Associated Antigen 8 may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.

Poids moléculaire: 46kD

ID gène: 26206

UniProt: Q99932