TAL1 anticorps (pSer122)

N° du produit ABIN7224604

Cet anticorps anti-TAL1 Polyclonal Lapin (ABIN7224604) détecte spécifiquement TAL1 dans WB, ELISA et IHC (p). L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour TAL1 anticorps (pSer122) (ABIN7224604)

Antigène: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAL1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TAL1 anticorps

Épitope: pSer122

Fonction: TAL1 (phospho Ser122) Polyclonal Antibody

Specificité: Phospho-TAL1 (S122) Polyclonal Antibody detects endogenous levels of TAL1 protein only when phosphorylated at S122.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from human TAL1 Phospho-Ser122

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:10000). Not yet tested in other applications.

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur TAL1

Antigène: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Autre désignation: TAL1

Sujet: Rabbit Anti-TAL1 (phospho Ser122) Polyclonal Antibody,TAL1, BHLHA17, SCL, TCL5, T-cell acute lymphocytic leukemia protein 1, TAL-1, Class A basic helix-loop-helix protein 17, bHLHa17, Stem cell protein, T-cell leukemia/lymphoma protein 5,The basic helix-loop-helix (bHLH) family of transcription factors play roles in a variety of developmental and adult biological settings. The basic (b) domain of bHLH transcription factors allows association with DNA, while the HLH domain facilitates the mono- and heterodimeric interactions required for efficient DNA binding. TAL1, also known as SCL, is a bHLH transcription factor that plays an essential role in the generation of embryonic hematopoietic stem cells , and is required for maturation of erythroid and megakaryocytic lineages in the adult. TAL1 interacts with Lim-domain containing proteins LMO2 and Ldb1, and has been found in complexes with these proteins as well as the hematopoietic transcription factor GATA-1. Both TAL1 and LMO2 have been associated with T-cell acute lymphoblastic leukemia (T-ALL). TAL1 activity is essential for both hematopoiesis and neurogenesis.,T-cell acute lymphocytic leukemia protein 1

Poids moléculaire: observerd band 45kDa

ID gène: 6886

UniProt: P17542

Pathways: Stem Cell Maintenance