TCL1A anticorps (AA 30-110)

N° du produit ABIN7231744

Cet anticorps anti-TCL1A Polyclonal Lapin (ABIN7231744) détecte spécifiquement TCL1A dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour TCL1A anticorps (AA 30-110) (ABIN7231744)

Antigène: TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TCL1A est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TCL1A anticorps

Épitope: AA 30-110

Fonction: Rabbit Anti-Tcl1 Polyclonal Antibody

Specificité: The antibody detects endogenous levels of Tcl1

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human Tcl1 protein at AA range: 30-110

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:10000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur TCL1A

Antigène: TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))

Autre désignation: Tcl1

Sujet: T-cell leukemia/lymphoma protein 1A, Oncogene TCL-1, Oncogene TCL1, Protein p14 TCL1Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al. 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) TCL1A (T-Cell Leukemia/Lymphoma 1A) is a Protein Coding gene. Diseases associated with TCL1A include Precursor T-Cell Acute Lymphoblastic Leukemia and T-Cell Leukemia. Among its related pathways are PI3K-Akt signaling pathway and PI3K / Akt Signaling. An important paralog of TCL1A is MTCP1.

Poids moléculaire: 13kD

ID gène: 8115

UniProt: P56279

Pathways: Stem Cell Maintenance