Thyroglobulin anticorps (AA 2511-2560)

N° du produit ABIN7231792

Cet anticorps Lapin Polyclonal détecte spécifiquement Thyroglobulin dans IHC, ELISA et IF. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Thyroglobulin anticorps (AA 2511-2560) (ABIN7231792)

Antigène: Thyroglobulin (TG)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Thyroglobulin est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-Thyroglobulin anticorps

Épitope: AA 2511-2560

Fonction: Rabbit Anti-Thyroglobulin Polyclonal Antibody

Specificité: The antibody detects endogenous levels of Thyroglobulin

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human Thyroglobulin protein at AA range: 2511-2560

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200,ELISA 1:10000-20000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Thyroglobulin

Antigène: Thyroglobulin (TG)

Autre désignation: Thyroglobulin

Sujet: Thyroglobulin, TgThyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in Thyroglobulin are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. Diseases associated with TG include Thyroid Dyshormonogenesis 3 and Familial Thyroid Dyshormonogenesis.

ID gène: 7038

UniProt: P01266

Pathways: Thyroid Hormone Synthesis