Metabotropic Glutamate Receptor 5 anticorps (C-Term)

N° du produit ABIN7233043

Cet anticorps Souris Monoclonal détecte spécifiquement Metabotropic Glutamate Receptor 5 dans WB, IHC, IP et IF/ICC. Il présente une réactivité envers Rat.

Aperçu rapide pour Metabotropic Glutamate Receptor 5 anticorps (C-Term) (ABIN7233043)

Antigène: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Metabotropic Glutamate Receptor 5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (fixed cells) (IF/ICC)

Clone: S75-3

Détail du produit anti-Metabotropic Glutamate Receptor 5 anticorps

Épitope: AA 824-1203, C-Term

Fonction: Anti-mGluR1/5 Glutamate Receptor Mouse Monoclonal Antibody

Specificité: This antibody recognizes human, mouse, and rat mGluR1 and mGluR5.

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein G affinity chromatography.

Immunogène: Fusion protein corresponding to aa 824-1203 (cytoplasmic C-terminus) of rat mGluR5b (accession no. P31424).

Isotype: IgG2a

Information d'application

Indications d'application: Immunoblotting: use at 1 μg/mL. A band of ~130 kDa is detected. Smaller fragments due to proteolysis are detected as well.
Positive control: Rat brain lysate.
These are recommended concentrations. User should determine optimal concentrations for their application.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: Lot specific

Buffer: PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: This antibody is stable for at least one (1) year at -20°C.

Détails sur Metabotropic Glutamate Receptor 5

Antigène: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Autre désignation: Grm5

Sujet: Metabotropic glutamate receptor 5,G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium sPubMed:1320017, PubMed:21795692}.,The metabotropic glutamate receptors (mGluRs) are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs. Like all glutamate receptors, mGluRs bind glutamate which functions as an excitatory neurotransmitter. Metabotropic glutamate receptors are not ion channels. Instead, they activate biochemical cascades, leading to the modification of other proteins. This can lead to changes in the synapse's excitability. Eight different types of mGluRs, designated mGluR1 to mGluR8, are divided into groups I, II, and III. Receptor types are grouped based on receptor structure and physiological activity.,Cell membrane, Multi-pass membrane protein,mGluR5

UniProt: P31424

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity