MAPT anticorps

N° du produit ABIN7233074

L’anticorps anti-MAPT Monoclonal Souris est utilisé pour la détection de MAPT dans des échantillons de Humain. Il a été validé pour WB, ELISA, IF/ICC et DB.

Aperçu rapide pour MAPT anticorps (ABIN7233074)

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAPT est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (fixed cells) (IF/ICC), Dot Blot (DB)

Clone: 1D5

Détail du produit anti-MAPT anticorps

Fonction: Anti-Tau Mouse Monoclonal Antibody

Specificité: This antibody recognizes human, mouse, and rat Tau.

Réactivité croisée: Humain, Souris, Rat

Immunogène: Full-length recombinant human Tau441 (2N4R) P301S mutant protein pre-formed fibrils. In humans, mutation P301S gives rise to early-onset dementia.

Information d'application

Indications d'application: Immunoblotting: use at 1-5 μg/mL. A band of ~45.8 kDa is detected.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 0.09 % sodium azide, 50 % glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: This product is stable for at least one (1) year at -20°C.

Détails sur MAPT

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Autre désignation: MAPT

Sujet: Microtubule-associated protein tau,Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {PubMed:21985311, PubMed:32961270}.,Cytoplasm, cytosol, Cell membrane, Cytoplasm, cytoskeleton, Cell projection, axon, Cell projection, dendrite, Secreted,Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau

UniProt: P10636

Pathways: Signalisation MAPK, Dynamique des Microtubules, M Phase, Regulation of Cell Size