CACNA1C anticorps (Intracellular)

N° du produit ABIN7237612

L’anticorps anti-CACNA1C Polyclonal produit chez le Lapin a été validé pour IHC, WB, IP et IF. Il convient pour la détection de CACNA1C dans des échantillons provenant de Rat. }

Aperçu rapide pour CACNA1C anticorps (Intracellular) (ABIN7237612)

Antigène: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CACNA1C est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-CACNA1C anticorps

Épitope: AA 1506-1524, Intracellular

Fonction: A Rabbit Pan Polyclonal Antibody to CaV1 and CaV2 Subunits

Specificité: Intracellular, C-terminal region.

Réactivité croisée: Humain, Souris, Rat

Homologie: CaV1 family (α1C,α1D,α1F,α1S) from all known species - identical, CaV2 family (α1A,α1B,α1E) from all known species - 17,19 amino acid residues identical

Attributs du produit: Intracellular, C-terminal region.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)DNFDYLTRDWSILGPHHLD, corresponding to amino acid residues 1506-1524 of rat CaV1.2

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Commentaires:

Cited Application: IP|IHC

Negative Control: (ABIN7235043)

Blocking Peptide: (ABIN7235043)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur CACNA1C

Antigène: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Autre désignation: CACNA1C

Sujet: Voltage-dependent L-type calcium channel subunit alpha-1C, Cacna1c,Ca2+ ions regulate many cellular processes such as secretion, proliferation, and apoptosis and they are also cofactors of many proteins.1,2 In neurons, Ca2+ entry through voltage-dependent Ca2+ (CaV) channels triggers neurotransmitter release. Fast synaptic transmission in the mammalian central nervous system (CNS) is mediated by several high voltage-dependent Ca2+ channels.3Five types of Ca2+ channels are expressed in the CNS: the L-type (CaV1), N-type (CaV2.2), P/Q-type (CaV2.1), R-type (CaV2.3), and the T-type (CaV3).4 Each CaV channel is a multimeric protein composed of a pore forming α1 subunit and the auxiliary β (CaVβ), α2δ and γ subunits. There are four known CaVβ subunits, in addition to four α2δ subunits and eight γ subunits.4

Alternative names: CaVpan alpha1,

ID gène: 24239

NCBI Accession: NM_000719

UniProt: P22002

Pathways: Hormone Transport, Carbohydrate Homeostasis