NPX1 anticorps (Secreted)

N° du produit ABIN7237737

Cet anticorps anti-NPX1 Polyclonal Lapin (ABIN7237737) détecte spécifiquement NPX1 dans WB et IHC. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour NPX1 anticorps (Secreted) (ABIN7237737)

Antigène: NPX1 (Neuronal Pentraxin 1 (NPX1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPX1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-NPX1 anticorps

Épitope: AA 197-211, Secreted

Fonction: A Rabbit Polyclonal antibody to Neuronal Pentraxin 1 (NPTX1)

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat - identical, Human - 13 out of 15 amino acid residues identical

Attributs du produit: Secreted

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)ERAKIESALTSLHQR, corresponding to amino acid residues 197 - 211 of mouse NPTX1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236078)

Blocking Peptide: (ABIN7236078)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur NPX1

Antigène: NPX1 (Neuronal Pentraxin 1 (NPX1))

Autre désignation: NPTX1

Sujet:

Synonyms: Neuronal Pentraxin-1, NP1

Description: Neuronal Pentraxin 1 (NP1 or NPTX1) is a 47-50 kDa secreted glycoprotein that is expressed in the central nervous system and involved in excitatory synaptic remodeling1. The pentraxin superfamily members are made from monomers arranged in pentameric structures with a discoid shape. The family members are characterized by a 205 amino acids long conserved sequence located at C-terminal called the pentraxin domain with a shorter inner conserved sequence called the pentraxin signature 2.NP1 is preferentially expressed in the brain and is involved in glutamate receptor internalization. It is secreted pre-synaptically and implicated in excitatory synaptic and mitochondrial deficits. In addition, NP1 may represent a potential synapse-derived plasma biomarker that is able to identify alterations in excitatory synapses and early-onset Alzheimer's disease3.

ID gène: 18164

NCBI Accession: NM_018713

UniProt: Q62443

Pathways: Carbohydrate Homeostasis, Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals, SARS-CoV-2 Protein Interactome