AKT 1/2/3 anticorps (pSer472)

N° du produit ABIN7265522

L’anticorps Lapin Monoclonal anti-AKT 1/2/3 a été validé pour WB. Il convient pour détecter AKT 1/2/3 dans des échantillons de Humain.

Aperçu rapide pour AKT 1/2/3 anticorps (pSer472) (ABIN7265522)

Antigène: AKT 1/2/3

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp AKT 1/2/3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-AKT 1/2/3 anticorps

Épitope: pSer472

Fonction: Phospho-AKT1-S473+AKT2-S474+AKT3-S472 Rabbit mAb

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Phosphorylated Antibodies

Purification: Affinity purification

Immunogène: A phospho specific peptide corresponding to residues surrounding S473/S474/S472 of human AKT1/AKT2/AKT3

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur AKT 1/2/3

Antigène: AKT 1/2/3

Autre désignation: AKT1/AKT2/AKT3

Sujet: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011],AKT1/AKT2/AKT3,Protein phosphorylation,Protein phosphorylation,Protein phosphorylation,AKT1/AKT2/AKT3

Poids moléculaire: 48kDa/55kDa/51kDa/54kDa

ID gène: 207, 208, 10000

UniProt: P31749, P31751, Q9Y243