CHCHD2 anticorps (AA 75-145)

N° du produit ABIN7266448

Cet anticorps Lapin Polyclonal détecte spécifiquement CHCHD2 dans WB, IHC et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CHCHD2 anticorps (AA 75-145) (ABIN7266448)

Antigène: CHCHD2 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHCHD2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Classe de qualité: KO Validated

Détail du produit anti-CHCHD2 anticorps

Épitope: AA 75-145

Fonction: [KO Validated] CHCHD2 Rabbit pAb

Séquence: TLGHAITGGF SGGSNAEPAR PDITYQEPQG TQPAQQQQPC LYEIKQFLEC AQNQGDIKLC EGFNEVLKQC R

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 75-145 of human CHCHD2 (NP_057223.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CHCHD2

Antigène: CHCHD2 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2))

Autre désignation: CHCHD2

Sujet: The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants.,CHCHD2,C7orf17,MNRR1,NS2TP,PARK22,Cell Biology & Developmental Biology,CHCHD2

Poids moléculaire: 15kDa

ID gène: 51142

UniProt: Q9Y6H1