GSTM1 anticorps (AA 1-181)

N° du produit ABIN7267443

Détail du produit anti-GSTM1 anticorps

Antigène: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Épitope: AA 1-181

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GSTM1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Fonction: GSTM1 Rabbit pAb

Séquence: MPMILGYWDI RGLAHAIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL PYLIDGAHKI TQSNAILCYI ARKHNLCGET EEEKIRVDIL ENQTMDNHMQ LGMICYNPEF EKLKPKYLEE LPEKLKLYSE FLGKRPWFAG NKGLEKISAY MKSSRFLPRP VFSKMAVWGN K

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human GSTM1 (NP_666533.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur GSTM1

Antigène: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Autre désignation: GSTM1 (GSTM1 Produits)

Synonymes: anticorps GST1, anticorps GSTM1-1, anticorps GSTM1a-1a, anticorps GSTM1b-1b, anticorps GTH4, anticorps GTM1, anticorps H-B, anticorps MU, anticorps MU-1, anticorps GSTA3, anticorps Gstb-1, anticorps Gstb1, anticorps gst-mu, anticorps gst1, anticorps gstm1, anticorps gstm2, anticorps gth4, anticorps gtm1, anticorps glutathione S-transferase mu 1, anticorps glutathione S-transferase M1, anticorps glutathione S-transferase, mu 1, anticorps glutathione S-transferase Mu 1, anticorps glutathione S-transferase mu 2 (muscle), anticorps glutathione S-transferase mu 1 L homeolog, anticorps GSTM1, anticorps Gstm1, anticorps LOC100356307, anticorps GSTM2, anticorps LOC100731426, anticorps gstm1.L

Sujet: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008],GST1;GSTM1-1;GSTM1a-1a;GSTM1b-1b;GTH4;GTM1;H-B;MU;MU-1;GSTM1,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Drug metabolism,GSTM1

Poids moléculaire: 21kDa/25kDa

ID gène: 2944

UniProt: P09488

Pathways: Negative Regulation of Transporter Activity