LDLR anticorps (C-Term)

N° du produit ABIN7268296

Détail du produit anti-LDLR anticorps

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LDLR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Fonction: [KO Validated] LDL Receptor (LDLR) Rabbit pAb

Séquence: VFLCLGVFLL WKNWRLKNIN SINFDNPVYQ KTTEDEVHIC HNQDGYSYPS RQMVSLEDDV A

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Classe de qualité: KO Validated

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 800 to the C-terminus of human LDL Receptor (LDLR) (NP_000518.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur LDLR

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Autre désignation: LDLR (LDLR Produits)

Synonymes: anticorps FH, anticorps FHC, anticorps LDLCQ2, anticorps Hlb301, anticorps LDLRA, anticorps LDLA, anticorps LDL receptor-2, anticorps fhc, anticorps ldlcq2, anticorps ldlr, anticorps ldlr2-a, anticorps LDL receptor 1, anticorps ldlr-a, anticorps ldlr-b, anticorps low density lipoprotein receptor, anticorps low density lipoprotein receptor a, anticorps low density lipoprotein receptor S homeolog, anticorps low density lipoprotein receptor L homeolog, anticorps LDLR, anticorps Ldlr, anticorps ldlra, anticorps ldlr.S, anticorps ldlr.L

Sujet: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.,LDLR,FH,FHC,LDLCQ2,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Cardiovascular,Heart,Lipids,Cardiovascular diseases,Heart disease,LDLR

Poids moléculaire: 75kDa/76kDa/82kDa/90kDa/95kDa

ID gène: 3949

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism