MAP3K3 anticorps (AA 1-220)

N° du produit ABIN7268652

Détail du produit anti-MAP3K3 anticorps

Antigène: MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))

Épitope: AA 1-220

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP3K3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Fonction: MEKK3 Rabbit pAb

Séquence: MDEQEALNSI MNDLVALQMN RRHRMPGYET MKNKDTGHSN RQKKHNSSSS ALLNSPTVTT SSCAGASEKK KFLSDVRIKF EHNGERRIIA FSRPVKYEDV EHKVTTVFGQ PLDLHYMNNE LSILLKNQDD LDKAIDILDR SSSMKSLRIL LLSQDRNHNS SSPHSGVSRQ VRIKASQSAG DINTIYQPPE PRSRHLSVSS QNPGRSSPPP GYVPERQQHI

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human MEKK3 (NP_976226.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:100 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur MAP3K3

Antigène: MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))

Autre désignation: MAP3K3 (MAP3K3 Produits)

Synonymes: anticorps MAPKKK3, anticorps MEKK3, anticorps AW548911, anticorps Mekk3, anticorps mKIAA4031, anticorps mitogen activated protein kinase kinase kinase 3, anticorps mitogen-activated protein kinase kinase kinase 3, anticorps Map3k3, anticorps MAP3K3, anticorps map3k3

Sujet: This gene product is a 626-amino acid polypeptide that is 96.5 % identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively, it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.,MAP3K3,MAPKKK3,MEKK3,Signal Transduction,Kinase,Serine/threonine kinases,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Cytoskeleton,Actins,Immunology & Inflammation,B Cell Receptor Signaling Pathway,Toll-like Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,TLR Signaling,MAP3K3

Poids moléculaire: 70kDa/74kDa

ID gène: 4215

UniProt: Q99759

Pathways: Signalisation MAPK