p130 anticorps (AA 100-200)

N° du produit ABIN7269943

Cet anticorps Lapin Polyclonal détecte spécifiquement p130 dans WB et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour p130 anticorps (AA 100-200) (ABIN7269943)

Antigène: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p130 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-p130 anticorps

Épitope: AA 100-200

Fonction: RBL2 Rabbit pAb

Séquence: PTVSKGTVEG NYVSLTRILK CSEQSLIEFF NKMKKWEDMA NLPPHFRERT ERLERNFTVS AVIFKKYEPI FQDIFKYPQE EQPRQQRGRK QRRQPCTVSE I

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RBL2 (NP_005602.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur p130

Antigène: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Autre désignation: RBL2

Sujet: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.,RBL2,P130,Rb2,Epigenetics & Nuclear Signaling,Transcription Factors,RBL2

Poids moléculaire: 59kDa/128kDa

ID gène: 5934

UniProt: Q08999

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases