SARS-CoV-2 NSP13 anticorps

N° du produit ABIN7270148

L’anticorps anti-SARS-CoV-2 NSP13 Polyclonal Lapin est utilisé pour la détection de SARS-CoV-2 NSP13 dans des échantillons de SARS Coronavirus-2 (SARS-CoV-2). Il a été validé pour WB et IF.

Aperçu rapide pour SARS-CoV-2 NSP13 anticorps (ABIN7270148)

Antigène: SARS-CoV-2 NSP13 (HEL) (SARS-CoV-2 Helicase (NSP13) (HEL))

Reactivité: SARS Coronavirus-2 (SARS-CoV-2)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SARS-CoV-2 NSP13 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-SARS-CoV-2 NSP13 anticorps

Fonction: SARS-CoV-2 NSP13 Rabbit pAb

Réactivité croisée: SARS Coronavirus-2 (SARS-CoV-2)

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein of SARS-CoV-2 NSP13.

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SARS-CoV-2 NSP13

Antigène: SARS-CoV-2 NSP13 (HEL) (SARS-CoV-2 Helicase (NSP13) (HEL))

Autre désignation: NSP13

Classe de substances: Viral Protein

Sujet: [Spike protein S1]: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. Binding to host NRP1 and NRP2 via C-terminal polybasic sequence enhances virion entry into host cell. This interaction may explain virus tropism of human olfactory epithelium cells, which express high level of NRP1 and NRP2 but low level of ACE2. The stalk domain of S contains three hinges, giving the head unexpected orientational freedom. Uses human TMPRSS2 for priming in human lung cells which is an essential step for viral entry. Can be alternatively processed by host furin. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.,NSP13

ID gène: 43740578

UniProt: P0DTD1