Topoisomerase II alpha anticorps (AA 1050-1150)

N° du produit ABIN7270853

L’anticorps Lapin Polyclonal anti-Topoisomerase II alpha a été validé pour WB. Il convient pour détecter Topoisomerase II alpha dans des échantillons de Humain.

Aperçu rapide pour Topoisomerase II alpha anticorps (AA 1050-1150) (ABIN7270853)

Antigène: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Topoisomerase II alpha est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Topoisomerase II alpha anticorps

Épitope: AA 1050-1150

Fonction: DNA topoisomerase II alpha (TOP2A) Rabbit pAb

Séquence: NQARFILEKI DGKIIIENKP KKELIKVLIQ RGYDSDPVKA WKEAQQKVPD EEENEESDNE KETEKSDSVT DSGPTFNYLL DMPLWYLTKE KKDELCRLRN E

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human DNA topoisomerase II alpha (DNA topoisomerase II alpha (TOP2A)) (NP_001058.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Topoisomerase II alpha

Antigène: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Autre désignation: TOP2A

Sujet: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.,TOP2A,TOP2,TP2A,Epigenetics & Nuclear Signaling,Cancer,Drug resistance,Topoisomerases,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Centrosome,G2/M DNA Damage Checkpoint,TOP2A

Poids moléculaire: 174kDa/177kDa/178kDa/182kDa

ID gène: 7153

UniProt: P11388

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases