UBQLN4 anticorps (AA 300-390)

N° du produit ABIN7271124

Détail du produit anti-UBQLN4 anticorps

Antigène: UBQLN4 (Ubiquilin 4 (UBQLN4))

Épitope: AA 300-390

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBQLN4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Fonction: UBQLN4 Rabbit pAb

Séquence: QFGNNPFSSL AGNSDSSSSQ PLRTENREPL PNPWSPSPPT SQAPGSGGEG TGGSGTSQVH PTVSNPFGIN AASLGSGMFN SPEMQALLQQ I

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 300-390 of human UBQLN4 (NP_064516.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur UBQLN4

Antigène: UBQLN4 (Ubiquilin 4 (UBQLN4))

Autre désignation: UBQLN4 (UBQLN4 Produits)

Synonymes: anticorps a1u, anticorps cip75, anticorps ubin, anticorps ubiquilin-4, anticorps A1U, anticorps A1Up, anticorps C1orf6, anticorps CIP75, anticorps UBIN, anticorps A1u, anticorps AI663987, anticorps RGD1308273, anticorps ubiquilin 4 L homeolog, anticorps ubiquilin 4, anticorps ubqln4.L, anticorps ubqln4, anticorps UBQLN4, anticorps Ubqln4

Sujet: Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins. Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain. Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome. MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ. Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation. Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity. Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion.,UBQLN4,A1U,A1Up,C1orf6,CIP75,UBIN,Cell Biology & Developmental Biology,Ubiquitin,UBQLN4

Poids moléculaire: 24kDa/63kDa

ID gène: 56893

UniProt: Q9NRR5