UBD anticorps

N° du produit ABIN7271134

Détail du produit anti-UBD anticorps

Antigène: UBD (Ubiquitin D (UBD))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp UBD est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Fonction: FAT10/UBD Rabbit mAb

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: A synthesized peptide derived from human FAT10/UBD

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur UBD

Antigène: UBD (Ubiquitin D (UBD))

Autre désignation: UBD (UBD Produits)

Synonymes: anticorps FAT10, anticorps GABBR1, anticorps UBD-3, anticorps ubiquitin D, anticorps UBD, anticorps Ubd

Sujet: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2. Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs. May be involved in dendritic cell (DC maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV-associated nephropathy (HIVAN.,FAT10, GABBR1, UBD-3,Cell Biology & Developmental Biology,Immunology & Inflammation,Ubiquitin,UBD

Poids moléculaire: 23kDa

ID gène: 10537

UniProt: O15205

Pathways: Ubiquitin Proteasome Pathway