Topoisomerase II alpha anticorps

N° du produit ABIN7384013

Cet anticorps Lapin Polyclonal détecte spécifiquement Topoisomerase II alpha dans IHC et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Topoisomerase II alpha anticorps (ABIN7384013)

Antigène: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Topoisomerase II alpha est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-Topoisomerase II alpha anticorps

Purification: Affinity purification

Immunogène: Synthetic peptide of human TOP2A

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Topoisomerase II alpha

Antigène: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Autre désignation: TOP2A

Sujet: Alpha isozyme,ATP hydrolyzing DNA topoisomerase II alfa,DNA gyrase,DNA topoisomerase (ATP hydrolyzing),DNA topoisomerase 2 alpha,DNA topoisomerase 2-alpha,DNA topoisomerase II 170 kD,DNA topoisomerase II alpha isozyme,DNA topoisomerase II,DNA Topoisomerase2,TOP 2A,TOP2,TOP2A,TOP2A,Topoisomerase DNA II alpha 170 kDa,TP2A,This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

NCBI Accession: NP_001058

UniProt: P11388

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases