KEAP1 anticorps

N° du produit ABIN7384390

Cet anticorps anti-KEAP1 est un anticorps Lapin Monoclonal détectant KEAP1 dans WB et IHC (p). Adapté pour Humain et Souris.

Aperçu rapide pour KEAP1 anticorps (ABIN7384390)

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp KEAP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: R02-1H7

Détail du produit anti-KEAP1 anticorps

Purification: Affinity Purified

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000 IHC 1:20-1:50

Restrictions: For Research Use only

Stockage

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur KEAP1

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Autre désignation: Keap1

Sujet: Cytosolic inhibitor of Nrf2,INrf 2,INrf2,Keap 1,KEAP1,KEAP1,Kelch like ECH associated protein 1,Kelch like family member 19,Kelch like protein 19,Kelch-like ECH-associated protein 1,Kelch-like protein 19,KIAA0132,KLHL 19,KLHL19,MGC10630,MGC1114,MGC20887,MGC4407,MGC9454,KEAP1,also named as INRF2,KIAA0132 and KLHL19,is part of a multiprotein complex that contains the CUL3-ROC1 ubiquitin ligase,which can ubiquitinate the N-terminal domain of NRF2. Two molecules of KEAP1 bind to two distinct sites in the N-terminal region of NRF2,the ETGE and DLG sites,which affect the KEAP1-NRF2 interaction and/or its physiological consequences. KEAP1 retains NFE2L2/NRF2 in the cytosol. It functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. It also retains BPTF in the cytosol. This antibody is a mouse monoclonal antibody raised against residues near the C terminus of human KEAP1.

Poids moléculaire:

Observed_MW: 60/64kDa

Calculated_MW: 70kDa

ID gène: 9817

UniProt: Q14145

Pathways: Maintenance of Protein Location