NEDD4-2 anticorps (AA 275-325)

N° du produit ABIN7448685

Cet anticorps anti-NEDD4-2 est un anticorps Lapin Polyclonal détectant NEDD4-2 dans IHC. Adapté pour Humain et Souris.

Aperçu rapide pour NEDD4-2 anticorps (AA 275-325) (ABIN7448685)

Antigène: NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEDD4-2 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-NEDD4-2 anticorps

Épitope: AA 275-325

Fonction: Rabbit anti-NEDD4L IHC Antibody, Affinity Purified

Homologie: Rat,Bovine,Dog,Horse,Guinea pig_10141,Pig,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,Naked mole rat,African elephant,White-tufted-ear marmoset,Zebra finch,Crab-eating macaque

Purification: Affinity Purified

Immunogène: Between AA 275 and 325

Isotype: IgG

Information d'application

Indications d'application: 1:100 - 1:500

Restrictions: For Research Use only

Stockage

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur NEDD4-2

Antigène: NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))

Autre désignation: NEDD4L

Sujet: Background: NEDD4L (neural precursor cell expressed, developmentally down-regulated 4-like) functions as an E3 ubiquitin-protein ligase. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. It also promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5 [taken from the Universal Protein Resource (UniProt) wwwuniprotorg/uniprot/Q96PU5].

ID gène: 23327

NCBI Accession: NP_001138439

UniProt: Q96PU5

Pathways: Negative Regulation of Transporter Activity