RPA1 anticorps (AA 350-400)

N° du produit ABIN7448781

Cet anticorps anti-RPA1 est un anticorps Lapin Polyclonal détectant RPA1 dans IHC. Adapté pour Humain et Souris.

Aperçu rapide pour RPA1 anticorps (AA 350-400) (ABIN7448781)

Antigène: RPA1 (Replication Protein A1, 70kDa (RPA1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RPA1 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-RPA1 anticorps

Épitope: AA 350-400

Fonction: Rabbit anti-RPA70 IHC Antibody, Affinity Purified

Homologie: Rabbit,Orangutan,Monkey,Gorilla,Chimpanzee,Crab-eating macaque,White-tufted-ear marmoset,Northern white-cheeked gibbon,Tasmanian devil,Gray short-tailed opossum

Purification: Affinity Purified

Immunogène: Between AA 350 and 400

Isotype: IgG

Information d'application

Indications d'application: 1:100 - 1:500

Restrictions: For Research Use only

Stockage

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur RPA1

Antigène: RPA1 (Replication Protein A1, 70kDa (RPA1))

Autre désignation: RPA70

Sujet: Background: Replication protein A (RPA) is a multisubunit complex that carries out DNA mismatch repair (MMR) in association with MSH2 (a subunit of human MutS heterodimers), MLH1 (a subunit of human MutL heterodimers), PCNA, and DNA polymerase-delta. RPA is composed of a heterotrimer that includes subunits of 70 kDa (RPA1), 32 kDa (RPA2), and 14 kDa (RPA3). RPA1, the 70 kDa subunit, is an ssDNA binding protein that has been shown to be phosphorylated by ATM and ATR in response to DNA damage. In addition to a role in MMR, RPA also functions in the initiation of DNA replication and DNA unwinding at origins of replication.

ID gène: 6117

NCBI Accession: NP_002936

UniProt: P27694

Pathways: Telomere Maintenance, Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA