METTL14 anticorps (AA 75-125)

N° du produit ABIN7449065

L’anticorps Lapin Polyclonal anti-METTL14 a été validé pour IP. Il convient pour détecter METTL14 dans des échantillons de Humain.

Aperçu rapide pour METTL14 anticorps (AA 75-125) (ABIN7449065)

Antigène: METTL14 (Methyltransferase Like 14 (METTL14))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp METTL14 est non-conjugé

Application: Immunoprecipitation (IP)

Détail du produit anti-METTL14 anticorps

Épitope: AA 75-125

Fonction: Rabbit anti-METTL14 Antibody, Affinity Purified

Homologie: Orangutan

Purification: Affinity Purified

Immunogène: between AA 75 and 125

Isotype: IgG

Information d'application

Indications d'application: 15-20 μL/mg lysate

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur METTL14

Antigène: METTL14 (Methyltransferase Like 14 (METTL14))

Autre désignation: METTL14

Sujet: Background: METTL14 forms a heterodimer with METTL3, creating an N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). [taken from the Universal Protein Resource (UniProt) Q9HCE5].

ID gène: 57721

UniProt: Q9HCE5