p107 anticorps (AA 1018-1068)

N° du produit ABIN7449079

Cet anticorps Lapin Polyclonal détecte spécifiquement p107 dans IP. Il présente une réactivité envers Humain.

Aperçu rapide pour p107 anticorps (AA 1018-1068) (ABIN7449079)

Antigène: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p107 est non-conjugé

Application: Immunoprecipitation (IP)

Détail du produit anti-p107 anticorps

Épitope: AA 1018-1068

Fonction: Rabbit anti-RBL1 Antibody, Affinity Purified

Homologie: Mouse

Purification: Affinity Purified

Immunogène: Between AA 1018 and 1068

Isotype: IgG

Information d'application

Indications d'application: 6 - 15 μL/mg lysate

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur p107

Antigène: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Autre désignation: RBL1

Sujet: Background: Retinoblastoma-like protein 1 (RBL1) is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. RBL1 recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. RBL1 probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. It is a potent inhibitor of E2F-mediated trans-activation. RBL1 forms a complex with adenovirus E1A and with SV40 large T antigen and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RBL1 may act as a tumor suppressor [taken from the Universal Protein Resource (UniProt) P28749].

ID gène: 5933

UniProt: P28749

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases