FBXW7 anticorps (AA 1-50)

N° du produit ABIN7449880

Cet anticorps Lapin Polyclonal détecte spécifiquement FBXW7 dans WB et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour FBXW7 anticorps (AA 1-50) (ABIN7449880)

Antigène: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXW7 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-FBXW7 anticorps

Épitope: AA 1-50

Fonction: Rabbit anti-FBW7 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 1 and 50

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur FBXW7

Antigène: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Autre désignation: FBW7

Sujet: Background: FBW7 (F-box and WD repeat domain containing 7) is a member of the F-box family of proteins. The F-box is a protein-protein interaction motif first identified in cyclin F. F-box proteins associate with SCFs (Skp1-cullin-F-box protein ligase complexes) which are E3 ligases that ubiquitinate proteins and target them for proteasomal degradation. FBW7 has been found to bind and specifically target cyclin E and the Notch intracellular domain (NICD) for ubiquitination. Defects in FBW7 may contribute to tumorigenesis.

ID gène: 55294

NCBI Accession: NP_361014

UniProt: Q969H0

Pathways: Signalisation Notch, EGFR Signaling Pathway