PNP anticorps (AA 239-289)

N° du produit ABIN7450576

Cet anticorps Lapin Polyclonal détecte spécifiquement PNP dans WB et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour PNP anticorps (AA 239-289) (ABIN7450576)

Antigène: PNP (Purine Nucleoside Phosphorylase (PNP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PNP est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-PNP anticorps

Épitope: AA 239-289

Fonction: Rabbit anti-PNP Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 239 and 289

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur PNP

Antigène: PNP (Purine Nucleoside Phosphorylase (PNP))

Autre désignation: PNP

Sujet: Background: Purine nucleoside phosphorylase (PNP) is an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The PNP enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described [taken from NCBI Entrez Gene (Gene ID: 4860)].

ID gène: 4860

NCBI Accession: NP_000261

UniProt: P00491

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Ribonucleoside Biosynthetic Process, Positive Regulation of Response to DNA Damage Stimulus