TFEB anticorps (AA 325-375)

N° du produit ABIN7450813

Cet anticorps Lapin Polyclonal détecte spécifiquement TFEB dans WB et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour TFEB anticorps (AA 325-375) (ABIN7450813)

Antigène: TFEB (Transcription Factor EB (TFEB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TFEB est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-TFEB anticorps

Épitope: AA 325-375

Fonction: Rabbit anti-TFEB Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 325 and 375

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur TFEB

Antigène: TFEB (Transcription Factor EB (TFEB))

Autre désignation: TFEB

Sujet: Background: Transcription factor EB (TFEB) specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. TFEB specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thus, TFEB plays a central role in expression of lysosomal genes. TFEB also specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer [taken from the Universal Protein Resource (UniProt) P19484].

ID gène: 7942

NCBI Accession: NP_009093

UniProt: P19484