Neurofibromin 1 anticorps (AA 150-200)

N° du produit ABIN7451098

Cet anticorps Lapin Polyclonal détecte spécifiquement Neurofibromin 1 dans IP. Il présente une réactivité envers Humain.

Aperçu rapide pour Neurofibromin 1 anticorps (AA 150-200) (ABIN7451098)

Antigène: Neurofibromin 1 (NF1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neurofibromin 1 est non-conjugé

Application: Immunoprecipitation (IP)

Détail du produit anti-Neurofibromin 1 anticorps

Épitope: AA 150-200

Fonction: Rabbit anti-NF1 Antibody, Affinity Purified

Homologie: Mouse,Rat

Purification: Affinity Purified

Immunogène: Between AA 150 and 200

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. ABIN7451098 has not performed satisfactorily when used for WB of NF1 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of NF1.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur Neurofibromin 1

Antigène: Neurofibromin 1 (NF1)

Autre désignation: NF1

Sujet: Background: Inactivating mutations in NF1 (neurofibromin 1) result in neurofibromatosis type I (NF1) which is characterized by Schwann cell neurofibromas, café-au-lait spots, and benign lesions of the iris. At the cellular level, NF1 functions as a negative regulator of Ras activity. Loss of NF1 leads to increased levels of active Ras-GTP which is important for the formation and maintenance of Schwann cell tumors.

ID gène: 4763

NCBI Accession: NP_001035957

UniProt: P21359

Pathways: cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity