SUFUH anticorps (AA 434-484)

N° du produit ABIN7452074

L’anticorps Lapin Polyclonal anti-SUFUH a été validé pour WB et IP. Il convient pour détecter SUFUH dans des échantillons de Humain et Souris.

Aperçu rapide pour SUFUH anticorps (AA 434-484) (ABIN7452074)

Antigène: SUFUH (Suppressor of Fused Homolog (SUFUH))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUFUH est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-SUFUH anticorps

Épitope: AA 434-484

Fonction: Rabbit anti-SuFu Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 434 and 484

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur SUFUH

Antigène: SUFUH (Suppressor of Fused Homolog (SUFUH))

Autre désignation: SuFu

Sujet: Background: Suppressor of fused (SuFu) is a negative regulator of the hedgehog and beta-catenin signaling pathway. It down-regulates GLI1-mediated transactivation of target genes and is part of a corepressor complex that acts on DNA-bound GLI1. SuFu may also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Additionally, SuFu sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein [taken from the Universal Protein Resource (UniProt) Q9UMX1].

ID gène: 51684

NCBI Accession: NP_057253

UniProt: Q9UMX1

Pathways: Signalisation Hedgehog, Tube Formation, Maintenance of Protein Location