Sestrin 2 anticorps (AA 275-325)

N° du produit ABIN7452840

Cet anticorps anti-Sestrin 2 est un anticorps Lapin Polyclonal détectant Sestrin 2 dans WB et IP. Adapté pour Humain.

Aperçu rapide pour Sestrin 2 anticorps (AA 275-325) (ABIN7452840)

Antigène: Sestrin 2 (SESN2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sestrin 2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-Sestrin 2 anticorps

Épitope: AA 275-325

Fonction: Rabbit anti-SESN2 Antibody, Affinity Purified

Homologie: Mouse,Orangutan

Purification: Affinity Purified

Immunogène: between AA 275 and 325

Isotype: IgG

Information d'application

Indications d'application:

IP: 50-100 μL/mg lysate

WB: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur Sestrin 2

Antigène: Sestrin 2 (SESN2)

Autre désignation: SESN2

Sujet: Background: SESN2 functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. SESN2 may negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1, and may positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress, and has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein.  [taken from the Universal Protein Resource (UniProt) P58004].

ID gène: 83667

UniProt: P58004