SMG1 anticorps (AA 1625-1675)

N° du produit ABIN7452857

Détail du produit anti-SMG1 anticorps

Antigène: SMG1 (pi-3-Kinase-Related Kinase SMG-1 (SMG1))

Épitope: AA 1625-1675

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMG1 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit anti-SMG1 Antibody, Affinity Purified

Homologie: Mouse

Purification: Affinity Purified

Immunogène: between AA 1625 and 1675

Isotype: IgG

Information d'application

Indications d'application:

IP: Not recommended. A300-394A is recommended.

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur SMG1

Antigène: SMG1 (pi-3-Kinase-Related Kinase SMG-1 (SMG1))

Autre désignation: SMG1 (SMG1 Produits)

Synonymes: anticorps 61E3.4, anticorps ATX, anticorps LIP, anticorps 2610207I05Rik, anticorps 5430435M13Rik, anticorps C130002K18Rik, anticorps mKIAA0421, anticorps zgc:152973, anticorps SMG1, nonsense mediated mRNA decay associated PI3K related kinase, anticorps SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), anticorps SMG1 phosphatidylinositol 3-kinase-related kinase, anticorps Serine/threonine-protein kinase smg-1, anticorps SMG1, anticorps Smg1, anticorps smg1, anticorps smg-1

Sujet: Background: SMG1 is a PIKK (phosphoinositide 3-kinase related kinases) protein kinase that plays a key role in RNA surveillance via nonsense-mediated mRNA decay (NMD). SMG1 phosphorylates Upf1, a factor that possesses RNA helicase activity and is also central to NMD. SMG1 and UPF-1 have been shown to exist in a complex with the translation termination release factors eRF3, and eRF1. This complex has been termed SURF and associates with the exon junction complex (EJC) to function in the recognition of premature termination codons in aberrant RNAs to trigger NMD.

ID gène: 23049

UniProt: Q96Q15, Q96QV0

Pathways: Inositol Metabolic Process