SRRT anticorps (AA 826-876)

N° du produit ABIN7453421

L’anticorps Lapin Polyclonal anti-SRRT a été validé pour WB, IP et IHC (fp). Il convient pour détecter SRRT dans des échantillons de Humain et Souris.

Aperçu rapide pour SRRT anticorps (AA 826-876) (ABIN7453421)

Antigène: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SRRT est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-SRRT anticorps

Épitope: AA 826-876

Fonction: Rabbit anti-ARS2 Antibody, Affinity Purified

Homologie: Zebrafish,X. laevis,Bovine,Orangutan

Purification: Affinity Purified

Immunogène: Between AA 826 and 876

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur SRRT

Antigène: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Autre désignation: ARS2

Sujet: Background: Arsenate resistance protein 2 (ARS2) acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. ARS2 contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. ARS2 does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewa and does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity) [taken from the Universal Protein Resource (UniProt) Q9BXP5].

ID gène: 51593

NCBI Accession: NP_056992

UniProt: Q9BXP5

Pathways: Signalisation Notch, Stem Cell Maintenance