Recombinant EPAS1 anticorps (AA 400-450)

N° du produit ABIN7454018

Cet anticorps anti-EPAS1 est un anticorps Lapin Monoclonal détectant EPAS1 dans WB, IHC, IP, ICC, IF/ICC et ChIP-seq. Adapté pour Humain.

Aperçu rapide pour Recombinant EPAS1 anticorps (AA 400-450) (ABIN7454018)

Antigène: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp EPAS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (fixed cells) (IF/ICC), ChIP DNA-Sequencing (ChIP-seq)

Clone: BL-95-1A2

Détail du produit anti-EPAS1 anticorps

Épitope: AA 400-450

Fonction: Rabbit anti-HIF2-alpha Recombinant Monoclonal Antibody [BL-95-1A2]

Immunogène: between AA 400 and 450

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.09 % Sodium Azide, BSA-Free

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur EPAS1

Antigène: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Autre désignation: HIF2-alpha

Sujet: Background: The gene EPAS1 encodes for the transcription factor endothelial PAS domain-containing protein 1, and is induced as oxygen levels fall. Commonly called hypoxia inducible factor 2A (HIF2a), this protein is involved in the induction of oxygen regulated genes, binding to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. An important cancer biomarker, HIF2a may also play a role in Tibetan high-altitude adaptation (Am J Hum Genet. 2015 Jul 2, 97(1): 54-66.) and mutations in the EPAS1 gene are associated with erythrocytosis familial type 4 [taken from NCBI Entrez Gene (Gene ID: 2034) and UniProtKB (Entry: Q99814)].

ID gène: 2034

NCBI Accession: NP_001421

UniProt: Q99814

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, L'effet Warburg