Recombinant Polybromo 1 anticorps (AA 1-293)

N° du produit ABIN7454032

L’anticorps Lapin Monoclonal anti-Polybromo 1 a été validé pour WB, IHC, IP, ICC, FACS et IF (p). Il convient pour détecter Polybromo 1 dans des échantillons de Humain et Souris.

Aperçu rapide pour Recombinant Polybromo 1 anticorps (AA 1-293) (ABIN7454032)

Antigène: Polybromo 1 (PBRM1)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Polybromo 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Clone: BL-39-2C3

Détail du produit anti-Polybromo 1 anticorps

Épitope: AA 1-293

Fonction: Rabbit anti-PBRM1 Recombinant Monoclonal Antibody [BL-39-2C3]

Immunogène: residues 1-293

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.09 % Sodium Azide, BSA-Free

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur Polybromo 1

Antigène: Polybromo 1 (PBRM1)

Autre désignation: PBRM1

Sujet: Background: The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. PBRM1 is a component of the SWI/SNF-B (PBAF) complex. It contains six bromodomains which are defined by a 110 amino-acid module that interacts with acetylated lysine and is found in many chromatin binding proteins and histone acetyltransferases. PBRM1 has been proposed to function as a tumor suppressor protein. Recently, PBRM1 has been found to play a role in mediating cell cycle arrest in response to DNA damage via the regulation of the tumor suppressor p21.

ID gène: 55193

UniProt: Q86U86