TXNIP anticorps (AA 300-350)

N° du produit ABIN7454484

Cet anticorps Lapin Polyclonal détecte spécifiquement TXNIP dans IP et IHC (fp). Il présente une réactivité envers Humain.

Aperçu rapide pour TXNIP anticorps (AA 300-350) (ABIN7454484)

Antigène: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TXNIP est non-conjugé

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-TXNIP anticorps

Épitope: AA 300-350

Fonction: Rabbit anti-TXNIP Antibody, Affinity Purified

Homologie: Rat

Purification: Affinity Purified

Immunogène: between AA 300 and 350

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: Not recommended

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur TXNIP

Antigène: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Autre désignation: TXNIP

Sujet: Background: Thioredoxin-interacting protein (TXNIP) may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. TXNIP interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Also, TXNIP functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest [taken from the Universal Protein Resource (UniProt) Q9H3M7].

ID gène: 10628

NCBI Accession: NP_006463

UniProt: Q9H3M7

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome