DDB1 anticorps (C-Term)

N° du produit ABIN7454634

Cet anticorps Lapin Polyclonal détecte spécifiquement DDB1 dans WB, IP et IHC (fp). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour DDB1 anticorps (C-Term) (ABIN7454634)

Antigène: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDB1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-DDB1 anticorps

Épitope: C-Term

Fonction: Rabbit anti-DDB1 Antibody, Affinity Purified

Homologie: Rat,X. laevis,Bovine,Orangutan

Purification: Affinity Purified

Immunogène: between AA 1100 and C-term

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur DDB1

Antigène: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Autre désignation: DDB1

Sujet: Background: DDB1 (DNA Damage Binding Protein 1) is a subunit of the DNA damage-binding protein complex (DDB) involved in DNA repair. As part of a complex with Cul4-based ubiquitin ligase, Cul4-Ddb1 can directly modify chromatin through the ubiquitination of histones as well as ubiquitinate other chromatin bound factors. A deficiency in Cul4-Ddb1 ubiquitin ligase has been associated with xeroderma pigmentosum, a heritable disease characterized by defects in nucleotide excision repair and skin cancer development.

ID gène: 1642

UniProt: Q16531, Q13289

Pathways: Réparation de l'ADN