PKM2 anticorps (AA 1-50)

N° du produit ABIN7454938

L’anticorps Lapin Polyclonal anti-PKM2 a été validé pour WB, IP et IHC (fp). Il convient pour détecter PKM2 dans des échantillons de Humain.

Aperçu rapide pour PKM2 anticorps (AA 1-50) (ABIN7454938)

Antigène: PKM2 (Pyruvate Kinase M2 (PKM2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKM2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-PKM2 anticorps

Épitope: AA 1-50

Fonction: Rabbit anti-PKM2 Antibody, Affinity Purified

Homologie: Orangutan

Purification: Affinity Purified

Immunogène: Between AA 1 and 50

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur PKM2

Antigène: PKM2 (Pyruvate Kinase M2 (PKM2))

Autre désignation: PKM2

Sujet: Background: Pyruvate Kinase M2 (PKM2) is a glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. PKM2 also stimulates POU5F1-mediated transcriptional activation, and plays a general role in caspase independent cell death of tumor cells [taken from the Universal Protein Resource (UniProt) P14618].

ID gène: 5315

NCBI Accession: NP_002645

UniProt: P14618

Pathways: L'effet Warburg