beta Arrestin 1 anticorps (AA 368-418)

N° du produit ABIN7454956

L’anticorps Lapin Polyclonal anti-beta Arrestin 1 a été validé pour WB, IP et IHC (fp). Il convient pour détecter beta Arrestin 1 dans des échantillons de Humain.

Aperçu rapide pour beta Arrestin 1 anticorps (AA 368-418) (ABIN7454956)

Antigène: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp beta Arrestin 1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-beta Arrestin 1 anticorps

Épitope: AA 368-418

Fonction: Rabbit anti-Beta-Arrestin 1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 368 and 418

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur beta Arrestin 1

Antigène: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Autre désignation: Beta-Arrestin 1

Sujet: Background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Beta-arrestin 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions [taken from NCBI Entrez Gene (Gene ID: 408)].

ID gène: 408

NCBI Accession: NP_004032

UniProt: P49407

Pathways: Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction