Estrogen Receptor alpha anticorps (AA 1-190)

N° du produit ABIN7464705

Cet anticorps Souris Monoclonal détecte spécifiquement Estrogen Receptor alpha dans WB, FACS, IP et IHC (fro). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Estrogen Receptor alpha anticorps (AA 1-190) (ABIN7464705)

Antigène: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Estrogen Receptor alpha est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 1F3

Détail du produit anti-Estrogen Receptor alpha anticorps

Épitope: AA 1-190

Specificité: This antibody is specific for ER alpha protein, and it does not cross react with ER beta protein.

Réactivité croisée: Humain, Lapin

Purification: Protein G purified

Immunogène: The region encoding amino acids 1-190 expressed in E. coli.

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500-1:3000. IP: 1 - 5 μg/mL. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: MCF-7 , DDDDK-tagged ESR1-transfected 293T

Validation: Comparison, Orthogonal, Overexpression

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.56 mg/mL

Buffer: PBS, No Preservative

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur Estrogen Receptor alpha

Antigène: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Autre désignation: estrogen receptor 1

Sujet: Estrogen receptor 1 , ER , ESR , ESRA , ESTRR , Era , NR3A1,This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]

Poids moléculaire: 66 kDa

ID gène: 2099

UniProt: P03372

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly